The Role of Carnitine in Acetoacetate Production and Fatty Acid Synthesis.
نویسندگان
چکیده
منابع مشابه
Effect of carnitine on mitochondrial oxidation of palmitoylearnitine.
The effects of carnitine on the metabolism of palmitoylcarnitine were studied by using isolated rat liver mitochondria. Particular attention was given to carnitine acyltransferase-mediated interactions between carnitine and the mitochondrial CoA pool. Carnitine concentrations less than 1.25mm resulted in an increased production of acetylcarnitine during palmitoylcarnitine oxidation. Despite thi...
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The oxidation of [l-Wlpalmitate by isolated rat liver mitochondria was increased by calcium chloride, and was quantitatively accounted for by an increased production of ketone bodies facetoacetate plus /3-hydroxybutyrate). ‘%02 production was depressed by Ca2+. These changes were associated with an elevated /3-hydroxybutyrate:acetoacetate ratio, reflecting an increased mitochondrial NADH:NAD+ r...
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Conditions are described for perfusing rat livers in vitro which result in rates of fatty acid synthesis which equal the rates observed in vivo. Rates of 3-/3-hydroxysterol synthesis by the perfused liver are equal to or greater than those observed in vivo. Livers from starved animals perfused with low concentrations of glucose show low rates of fatty acid and 3-P-hydroxysterol synthesis. When ...
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Using isolated hepatocytes from fasted rats, the oral hypoglycemic agents, Z-tetradecylglycidic acid (McN3802) and its methyl ester (McN-3716) inhibited (concentrations down to 5 x lo-’ M) the oxidation of palmitate to CO2 and ketones but not the oxidation of octauoate or palmitoylcarnitine. The antiketogenic effect which occurs at concentrations as low as lo-’ M was accompanied by a lowered P-...
متن کاملMetabolism of L-Carnitine Esters of ,&&ibstituted Palmitic Acid by Rat Liver Mitochondria*
The chemical synthesis and properties of L-carnitine esters of P-ketopalmitic acid, /3-hydroxypslmitic acid, and ~ranstr,P-unsaturated palmitic acid are described. Isolated rat liver mitochondria oxidize the carnitine esters of these acids more efficiently than the free acids as judged by acetoacetate production and oxygen uptake. Rat liver mitochondrial extracts catalyze the conversion of palm...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 44 شماره
صفحات -
تاریخ انتشار 1965